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目的探讨慢性阻塞性肺疾病合并心律失常采用抗凝治疗的临床效果。方法选择安钢职工总医院2009年3月至2011年5月收治的慢性阻塞性肺疾病合并心律失常患者80例,随机分为两组,对照组40例采用常规治疗,观察组40例行抗凝治疗,对临床结果进行回顾性分析。结果观察组病情好转平均时间为(4.5±2.1)d,平均住院时间为(9.5±3.5)d;对照组病情平均好转时间为(6.9±3.7)d,平均住院时间为(12.9±5.8)d。两组比较差异有统计学意义(P<0.05)。观察组血清降钙素原(PCT)、白细胞介素-6、血浆纤维蛋白原及APACHEⅡ评分水平下降值变化情况优于对照组,差异有统计学意义(P<0.05)。结论抗凝治疗可缩短患者住院时间,临床症状好转,患者高黏滞、高凝血栓形成前状态得到明显改善,降低了肺小动脉血栓形成,缓解了患者心律失常程度,降低了治疗费用,明显提高了临床效果和患者生存质量。
Objective To investigate the clinical effect of anticoagulant therapy on chronic obstructive pulmonary disease with arrhythmia. Methods All patients 80 patients with chronic obstructive pulmonary disease and arrhythmia admitted from March 2009 to May 2011 in General Hospital of Anyang Iron and Steel Company were randomly divided into two groups. Control group, 40 cases were treated by conventional therapy, 40 cases in observation group Coagulation therapy, the clinical results of a retrospective analysis. Results The mean time to improvement in the observation group was (4.5 ± 2.1) days and the average length of hospital stay was (9.5 ± 3.5) days. The mean improvement time in the control group was (6.9 ± 3.7) days and the average length of stay was (12.9 ± 5.8) days . The difference between the two groups was statistically significant (P <0.05). The changes of serum procalcitonin (PCT), interleukin-6, plasma fibrinogen and APACHEⅡscore levels in observation group were better than those in control group, with statistical significance (P <0.05). Conclusion Anticoagulant therapy can shorten the length of hospital stay, clinical symptoms improved, patients with high viscosity, thrombosis before the state has been significantly improved, reducing pulmonary arterial thrombosis, ease the patient arrhythmia, reduce the cost of treatment, significantly Improve the clinical effect and quality of life of patients.