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为了解在小儿中骶管注用咪唑安定的镇痛效果,选择45例行单侧腹股沟斜疝修补术的男性患儿(ASAⅠ级)为研究对象。此45例患儿均未用术前药,以N_2O-O_2-氟烷行麻醉诱导和维持,在术中不给镇静药和阿片类药物。手术结束时随机将患儿等分为三组:分别骶管内注入0.25％丁哌卡因1ml·kg~(-1)(组Ⅰ);0.25％丁哌卡因1ml·kg~(-1)加50μg·kg~(-1)咪唑安定(组Ⅱ);咪唑安定50μg·kg~(-1)加生理盐水1ml·kg~(-1)(组Ⅲ)(三组的年龄体重相仿)。注药后均按计划观察并记录疼痛评分(按6分法,即无疼痛或轻度疼痛1～2分,中度疼痛3～4分,严重疼痛5～6分),行为评分(按3分法,即精神愉快、安静不动、精神紧张躁动)和呼吸频率、血压、心率的变化,并且观察术后6h时患儿独立站立的能力。
To understand the analgesic effect of midazolam in infantile caudalis, 45 ASA grade Ⅰ patients with unilateral inguinal hernia repair were selected as the study subjects. None of the 45 children received preoperative medication and were induced and maintained with N 2 O 2 O-fluoro-anesthesia. Sedation and opioids were not given during the operation. At the end of surgery, the children were randomly divided into three groups: 0.25% bupivacaine (1ml · kg -1) (group Ⅰ), 0.25% bupivacaine 1ml · kg -1 Add 50μg · kg ~ (-1) midazolam (group Ⅱ); 50mg · kg -1 of midazolam and 1ml · kg -1 of normal saline (group Ⅲ). Pain after injection were observed and recorded according to the plan of pain score (by 6 points, that is, no pain or mild pain 1 to 2 minutes, moderate pain 3 to 4 minutes, severe pain 5 to 6 minutes), behavioral score (press 3 Sub-method, that is happy, quiet, nervous restlessness) and respiratory rate, blood pressure, heart rate changes, and observe the ability of children standing independently 6h after surgery.