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糖尿病肾病 (ＤＮ)是糖尿病常见而且严重的慢性并发症 ,高血糖和血管紧张素Ⅱ (ＡｎｇⅡ )是导致ＤＮ肾纤维化最主要的两种物质 ,它们通过共同的信号传导途径参与了肾纤维化的发生发展〔1,2〕。近年来 ,国外研究发现结缔组织生长因子 (ｃｏｎｎｅｃｔｉｖｅｔｉｓｓｕｅｇｒｏ
Diabetic nephropathy (DN) is a common and serious chronic complication of diabetes mellitus. Hyperglycemia and angiotensin II (Ang II) are the two most important substances leading to DN renal fibrosis. They are involved in renal fibrosis through a common signaling pathway The occurrence and development [1,2]. In recent years, foreign studies have found that connective tissue growth factor (connective tissue)