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本文报告强心药黄麻甲甙的治疗作用强度、治疗宽度并与已知强心药作比较性研究。在豚鼠、猫心肺制备上,以戊巴比妥钠引起心力衰竭(少数自发性心力衰竭),分别测定了黄麻甲甙、哇巴因、康毗丁的治疗作用及治疗宽度,以输出量或静脉压的改善作为、“治疗量”的指标;以静脉压重又上升,波幅加大,心律不齐作为“中毒量”指标;以发生心室纤维颤动作为“致死量”指标;计算了三种药物的治疗量/致死量、中毒量/致死量的百分率,黄麻甲甙在二种心肺制备上,对心力衰竭有良好的治疗作用,其治疗量在猫身上小于哇巴因;在豚鼠身上则与哇巴因相近,不仅作用较强,而且作用较其他二种已知强心甙发生得更早。 在治疗量/致死量的百分率方面,在豚鼠心肺制备上,黄麻甲甙为6.05％、哇巴因17.45％、康毗丁14.41％。在猫心肺制备上则分别为10.86％、21.29％及22.96％;即黄麻甲甙的治疗宽度为上述二种强心甙的2～3倍,在统计学上有显著性差异。在中毒量/致死量的百分率方面,三种强心甙差异不大。本文对豚鼠心肺制备的实验方法及其作为测定强心甙治疗宽度的工具,作了简短的讨论。
This article reports the strength of treatment, the width of treatment, and the comparative study with known cardiotoxic agents. In guinea pigs and cats, the cardiopulmonary preparation was induced by pentobarbital sodium (a handful of spontaneous heart failure), and the therapeutic effects and therapeutic widths of jutectin, ouabain, The improvement of venous pressure was taken as the index of “therapeutic dose”; venous pressure rose again, amplitude increased, arrhythmia was taken as an indicator of “poisoning volume”; ventricular fibrillation was taken as the indicator of “lethal dose”; three Therapeutic / lethal dose of drug, percentage of lethal dose / lethal dose, jaundice in the preparation of two kinds of heart and lungs, has a good therapeutic effect on heart failure, the treatment of cats in the body is less than ouabain; Similar to ouabain, not only the role of strong, and the role than the other two known cardiac glycosides occurred earlier. In terms of the amount of treatment / lethality, in guinea-pig cardiopulmonary preparation, jaundice is 6.05%, ouabain 17.45%, and kapudine 14.41%. In cardiopulmonary preparation, they were 10.86%, 21.29% and 22.96%, respectively; that is, the therapeutic width of jaundice was 2 to 3 times higher than that of the above two kinds of cardiac glycosides, with statistically significant differences. In the amount of poisoning / lethal dose, the three kinds of cardiac glycosides little difference. In this article, a brief discussion of the experimental method of guinea pig heart-lung preparation and its use as a tool to measure the width of treatment of cardiac glycosides was made.