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5年内随访乳腺癌80例，腋淋巴结转移45例，腋淋巴结无转移35例；其中无瘤生存57例，带瘤生存4例，死亡19例。用链霉素酶生物蛋白-过氧化酶免疫组化染色法（S－P法）测定石蜡标本中组织蛋白酶D（Cath-D）和ER的表达。结果提示：（1）ER阳性表达与乳癌预后呈负相关．而Cath-D阳性表达与乳腺癌预后呈负相关；（2）Cath－D与淋巴结转移情况及肿瘤大小之间可能是相互独立的预后判断指标；（3）Cath-D作为评估无腋淋巴结转移的乳癌的预后具有较好的预测价值。
Follow-up of breast cancer was performed in 80 cases, axillary lymph node metastasis in 45 cases, and axillary lymph node metastasis in 35 cases within 5 years. Among them, 57 cases had no tumor survival, 4 cases had tumor survival, and 19 cases died. Streptomycin enzyme-peroxidase immunohistochemical staining (S-P method) was used to determine the expression of cathepsin D (Cath-D) and ER in paraffin-embedded specimens. The results suggest that: (1) The positive expression of ER is negatively correlated with the prognosis of breast cancer. The positive expression of Cath-D was negatively correlated with the prognosis of breast cancer. (2) The correlation between Cath-D and lymph node metastasis and tumor size may be independent predictors of prognosis; (3) Cath-D was used as a marker to assess the absence of lymph node metastasis. The prognosis of breast cancer has a good predictive value.