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目的分析我院门诊抗菌药物的使用情况,促进临床合理应用抗菌药物。方法利用计算机统计2013年1~6月各种抗菌药物的门诊使用数量,计算用药频度(DDDs),并对DDDs进行排序分析;从2013年1~6月门诊处方中随机抽取6000张,分析抗菌药物应用的合理性。结果我院门诊抗菌药物DDDs排序前三位的依次是注射用阿莫西林钠舒巴坦钠、乳酸左氧氟沙星注射液、注射用盐酸克林霉素;门诊抗菌药物的使用率为25.7%,其中使用两种抗菌药物的处方占使用抗菌药物处方23.9%;不合理应用抗菌药物的处方375张,占抗菌药物处方24.3%,不合理之处主要是选用指征不明确、用法用量不当、重复用药、溶媒选择不当、药理拮抗等。结论我院门诊抗菌药物应用基本合理,但仍需进一步加强抗菌药物处方的点评与干预,规范抗菌药物的合理应用,以延缓细菌耐药。
Objective To analyze the use of antibacterials in outpatient clinics in our hospital and promote the rational use of antibacterials in clinics. Methods The number of outpatients for various antimicrobial agents was calculated by computer from January to June in 2013, DDDs were calculated, and DDDs were sorted and analyzed. From the outpatient prescriptions in January-June 2013, 6,000 were randomly selected for analysis. Rational use of antibacterial drugs. Results The order of top three DDDs of outpatient antimicrobial agents were as follows: amoxicillin sodium and sulbactam sodium injection, levofloxacin lactate injection and clindamycin hydrochloride injection; the use rate of outpatient antibacterials was 25.7% The two prescriptions for antimicrobial drugs accounted for 23.9% of the prescriptions for the use of antimicrobial drugs; 375 prescriptions for unreasonable use of antimicrobial drugs accounted for 24.3% of the prescriptions for antimicrobial drugs. Irrational indications were mainly ambiguous indications, improper usage, repeated medication, Improper solvent selection, pharmacological antagonism and so on. Conclusion The application of antimicrobial agents in our hospital is basically reasonable, but the comments and interventions on prescription of antimicrobial agents still need to be further strengthened, and the rational application of antimicrobial agents should be standardized to delay the drug resistance of bacteria.