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５５例新鲜食管癌冰冻切片用ＩＳＨ检测ＨＰＶ感染状况，４５例阳性，阳性率８１．８％。不同病变ＨＰＶ感染率不同，正常（８７．５０％）和单纯增生（８１．４０％）感染率明显高于原位癌（３８．３９％）和浸润癌（２７．２７％），不典型增生居中（６４．７０％）；而且不同病变ＩＳＨ阳性信号分布特征不同，在正常和单纯增生上皮呈层状分布，表层阳性细胞数多，信号强；原位癌层状分布特征消失，较弥散，浸润癌呈区域性阳性。本实验表明汕头食管癌组织ＨＰＶ感染率高，ＨＰＶ１８可能在该地区食管癌的发病过程中起重要作用。
Fifty-five fresh frozen sections of esophageal cancer were detected by ISH for HPV infection. 45 cases were positive and the positive rate was 81.8%. The infection rates of different lesions were different. The infection rate of normal (87.50%) and simple hyperplasia (81.40%) was significantly higher than that of in situ carcinoma (38.39%) and invasive carcinoma (27.27%). Centered (64.70%); and different lesions ISH positive signal distribution characteristics are different, in the normal and simple proliferation of epithelial layered distribution, the surface of positive cells and more signals strong; in situ cancer layered disappearance of the characteristics, more diffuse, Invasive carcinomas are regionally positive. This experiment shows that the HPV infection rate of the esophageal cancer tissues in Shantou is high, and HPV18 may play an important role in the pathogenesis of esophageal cancer in this area.