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目的观察阿卡波糖对老年糖耐量减低患者颈动脉内中膜厚度的影响。方法120例老年糖耐量减低患者分为两组:60例口服阿卡波糖50 mg,3次.d-1,持续1年,60例未服药,均随访1年。结果治疗后4周患者口服馒头餐后2 h血糖明显下降(P<0.01);1年后治疗组患者HbA1 c明显减低(P<0.05),平均颈动脉内中膜厚度增加治疗组明显低于对照组(P<0.05)。结论阿卡波糖有效降低糖耐量减低患者餐后血糖,长期治疗可降低糖化血红蛋白,减缓动脉粥样硬化的发展。
Objective To observe the effect of acarbose on carotid artery intima thickness in elderly patients with impaired glucose tolerance. Methods 120 elderly patients with impaired glucose tolerance were divided into two groups: 60 patients received acarbose 50 mg three times daily for 1 year, 60 patients were not taken and were followed up for 1 year. Results After 2 weeks of treatment, the blood glucose of oral steamed bread was significantly decreased 2 h after meal (P <0.01). After 1 year, the HbA1 c in the treated group was significantly decreased (P <0.05), and the mean carotid intima-media thickness was significantly lower in the treated group Control group (P <0.05). Conclusion Acarbose effectively reduces glucose tolerance and reduces postprandial blood glucose. Long-term treatment reduces glycated hemoglobin and slows the development of atherosclerosis.