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目的:观察血脂平冲剂对高脂血症大鼠血脂及血管内皮功能的影响。方法:将60只大鼠随机分为6组,一组为正常对照组,其他5组用高脂饲料造模,高脂血症大鼠模型成功后分为辛伐他汀治疗组,血脂平冲剂大、中、小治疗组,病理模型对照组。观察正常对照组、病理模型组,辛伐他汀治疗组和血脂平冲剂大、中、小治疗组对高脂血症大鼠血脂、血管内皮功能的影响和肝脏的病理变化。结果:各治疗组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(LDLC)均有明显的下降,而低密度脂蛋白(HDL-C)有明显升高,ET-1明显低于高脂血症病理模型组。结论:血脂平冲剂有明显的降血脂及改善血管内皮功能和预防脂肪肝形成的作用。
Objective: To observe the effect of Xuezhiping on blood lipids and vascular endothelial function in hyperlipidemic rats. Methods: 60 rats were randomly divided into 6 groups, one for the normal control group, the other five groups with high-fat diet modeling, hyperlipidemia rat model was divided into simvastatin treatment group, Xuezhiping granules Large, medium and small treatment group, pathological model control group. The effects of large, medium and small treatment groups of normal control group, pathological model group, simvastatin treatment group and Xuezhiping tablet on the blood lipid and endothelial function of hyperlipidemic rats and the pathological changes of the liver were observed. Results: The levels of total cholesterol (TC), triglyceride (TG) and high density lipoprotein (LDLC) in each treatment group were significantly decreased, while the levels of low density lipoprotein (HDL-C) Lower than hyperlipemia pathological model group. Conclusion: Xuezhiping Granule has obvious effect of lowering blood fat, improving endothelial function and preventing the formation of fatty liver.