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目的了解汉中市接受高效抗逆转录病毒治疗(HARRT)的人类免疫缺陷病病毒感染者/艾滋病患者(简称HIV/AIDS)治疗3年效果,为科学评价抗病毒治疗工作提供依据。方法采用回顾性调查方法。选择2005年6-11月首次在汉中接受国家免费抗病毒治疗,在基线、治疗后6、12、24、36个月均有CD4~+T淋巴细胞计数结果的89例患者进行回顾性分析,用SPSS 17.0软件分析不同治疗时间的CD4~+T淋巴细胞变化情况及影响因素。结果本次研究对象89例,其中男性74例(83.1%),女性15例(16.9%),男女性别比为4.9:1;最小年龄20岁,最大年龄80岁,平均年龄为(37.5±12.4)岁;已婚或同居39例(43.8%),未婚31例(34.8%),离异或丧偶19例(21.3%);传播途径中异性传播66例(74.2%),输血感染1例(1.1%),同性传播22例(24.7%)。入组时基线CD4~+T淋巴细胞均数为(205.5±113.5)个/μl,治疗6、12、24、36个月后的CD4~+T淋巴细胞均值分别为(359.1±184.4)、(375.7±182.7)、(447.5±217.2)、(464.0±212.9)个/μl。CD4~+T淋巴细胞计数均值总体差异有统计学意义(F=27.080,P<0.01)。治疗6、12、24、36个月的CD4~+T淋巴细胞计数较基线分别平均上升了(153.6±70.9)、(170.2±69.2)、(242±103.7)、(258.5±99.4)个/μl,CD4~+T淋巴细胞计数随治疗时间延长而提升,基线CD4~+T淋巴细胞计数、WHO临床分期是影响治疗后CD4~+T淋巴细胞计数提升的主要因素(F=38.000,P<0.01,F=2.993,P<0.05)。结论陕西省汉中市HIV/AIDS抗病毒治疗效果显著,治疗后CD4~+T淋巴细胞上升速度受多种因素影响。
Objective To understand the 3-year efficacy of human immunodeficiency virus (HIV / AIDS) patients receiving effective anti-retroviral therapy (HARRT) in Hanzhong and to provide evidence for the scientific evaluation of antiviral therapy. Methods The method of retrospective investigation was used. We chose the first free antiviral treatment in Hanzhong from June to November in 2005 and retrospective analysis of 89 patients with CD4 ~ + T lymphocyte counts at baseline, 6,12,24,36 months after treatment, The changes of CD4 ~ + T lymphocytes at different treatment time and its influencing factors were analyzed by SPSS 17.0 software. Results There were 89 cases in this study, including 74 males (83.1%) and 15 females (16.9%) with a sex ratio of 4.9: 1. The youngest was 20 years old and the oldest was 80 years old. The average age was (37.5 ± 12.4) ) Were married or cohabited, 39 (43.8%) were married or living together, 31 (34.8%) were unmarried, 19 (21.3%) were divorced or widowed, and there were 66 (74.2%) cases of heterosexual transmission and 1 %), Homosexual transmission in 22 cases (24.7%). The mean number of CD4 ~ + T lymphocytes in the baseline group was (205.5 ± 113.5) / μl at 6,12,24,36 months after admission, respectively (359.1 ± 184.4), ( 375.7 ± 182.7), (447.5 ± 217.2), (464.0 ± 212.9) / μl. The overall mean CD4 ~ + T lymphocyte count was statistically significant (F = 27.080, P <0.01). The counts of CD4 ~ + T lymphocytes at 6, 12, 24 and 36 months after treatment increased by an average of (153.6 ± 70.9), (170.2 ± 69.2), (242 ± 103.7) and (258.5 ± 99.4) / , CD4 ~ + T lymphocyte count increased with the prolongation of treatment time. Baseline CD4 ~ + T lymphocyte count and WHO clinical stage were the main factors affecting the increase of CD4 ~ + T lymphocyte count after treatment (F = 38.000, P <0.01 , F = 2.993, P <0.05). Conclusion Hanzhong City, Shaanxi Province HIV / AIDS anti-virus treatment effect is significant, after treatment, the rate of CD4 ~ + T lymphocytes increased by a variety of factors.