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已知的3种血管内皮生长因子受体(VEGFR)及其间的数量关系影响着血管形成的信号转导,血管内皮生长因子(VEGF)可介导肿瘤血管通透性增加并促进肿瘤血管形成,抑制VEGF和VEGFR的手段已用于肿瘤治疗的研究。VEGFR对肿瘤血管形成的影响还与Tie和Eph内皮酪氨酸家族等其他细胞表面受体
Known three kinds of vascular endothelial growth factor receptor (VEGFR) and the quantitative relationship between them affect the signal transduction of vascular formation, vascular endothelial growth factor (VEGF) can mediate the increase of tumor vascular permeability and promote tumor angiogenesis, The means of inhibiting VEGF and VEGFR have been used in the study of cancer therapy. The effect of VEGFR on tumor angiogenesis is also linked to other cell surface receptors such as the Tie and Eph endothelium tyrosine family