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目的:探讨引起IVF/ICSI-ET周期取消的相关因素以及如何减少这些因素导致的IVF/ICSI-ET周期的取消。方法:回顾性分析2005年1月～2008年1月安徽医科大学第一附属医院生殖医学中心75例被迫取消IVF/ICSI-ET周期患者的病历资料,并以100例取卵数≥4个、优质胚胎数≥2个患者的病历资料作为对照。结果:75例患者中,取卵前取消周期35例,移植前取消周期40例。研究组卵巢低反应者的年龄显著大于对照组(P<0.001);基础FSH值明显高于对照组(P<0.01);窦卵数少于对照组(P<0.001)。卵巢低反应、受精失败、OHSS、卵裂差、子宫内膜因素以及感染均为引起IVF/ICSI-ET周期取消的因素,其中卵巢低反应和受精失败为主要因素。结论:卵巢低反应、受精失败、OHSS、卵裂差、子宫内膜因素以及感染均可引起IVF/ICSI-ET周期取消,治疗前、治疗中减少这些因素,可以降低周期取消率。
OBJECTIVE: To investigate the factors that cause IVF / ICSI-ET cycle cancellation and how to reduce the IVF / ICSI-ET cycle cancellation due to these factors. Methods: The clinical data of 75 patients who were forced to cancel the IVF / ICSI-ET cycle from January 2005 to January 2008 in Reproductive Medicine Center of the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed. The number of 100 , The number of high-quality embryos ≥ 2 patients’ medical records as a control. Results: Of the 75 patients, 35 cases were withdrawn before ovulation and 40 cases were canceled before transplantation. The age of ovarian responders in study group was significantly higher than that in control group (P <0.001). The basal FSH value was significantly higher than that in control group (P <0.01). The number of sinusoids in study group was less than that in control group (P <0.001). Ovarian hyporesponse, failure of fertilization, OHSS, poor cleavage, endometrial factors and infection are the factors that cause the cancellation of IVF / ICSI-ET cycles. Low ovarian response and fertilization failure are the main factors. CONCLUSION: Ovarian hyporesponse, failure of fertilization, OHSS, poor cleavage, endometrial factors and infection can all cause the cancellation of IVF / ICSI-ET cycles. These factors can be reduced before and during treatment to reduce the cycle cancellation rate.