在过去二十年中,非类固醇抗炎药物(NSAID)已成为治疗儿童风湿病的主要药物,市售的新药有20多种,约半数不同程度地用于儿料。此类抗炎药物的共有特性在于抑制环氧化酶活性,该酶是花生四烯酸(AA)生物合成前列腺素(PG)的主要酶。治疗儿童风湿病的最常用NSAID有下列四类:(1)水扬酸盐类;(2)醋酸衍化物(如消炎痛、甲苯酰吡酸钠即痛灭定和苏灵大); Over the past two decades, non-steroidal anti-inflammatory drugs (NSAIDs) have become the leading drug for the treatment of childhood rheumatism. More than 20 new drugs are commercially available, about half of which are used to varying degrees. A common characteristic of such anti-inflammatory drugs is the inhibition of cyclooxygenase activity, which is the major enzyme for the biosynthesis of prostaglandins (PGs) by arachidonic acid (AA). The four most commonly used NSAIDs for the treatment of rheumatism in children are: (1) salicylates; (2) derivatives of acetic acid (such as indomethacin, sodium tolmetinate,