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单纯疱疹病毒胸苷激酶 (ＨＳＶ -ＴＫ) ,能将无毒或低毒的前药羟甲基无环鸟苷 (ｇａｎｃｉｃｌｏｕｖｉｒ,ＧＣＶ)磷酸化 ,并进一步在胞内代谢生成三磷酸ＧＣＶ。后者可抑制细胞内的ＤＮＡ聚合酶 ,通过阻断ＤＮＡ的合成而杀伤肿瘤细胞 ,并具有“旁观者效应”[1] 。共刺激分子Ｂ
Herpes simplex virus thymidine kinase (HSV-TK) phosphorylates ganciclouvir (GCV), a non-toxic or low-toxic prodrug, and further metabolizes triphosphate GCV in the cell. The latter inhibits intracellular DNA polymerase, killing tumor cells by blocking DNA synthesis and has a “bystander effect” [1]. Costimulatory molecule B