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目的探讨谷氨酰转肽酶(GGT)水平与代谢综合征(MS)的相关性,为临床治疗诊断提供依据。方法选取2011年5月至2012年2月在延边大学附属医院体检科进行健康体检的20岁以上成年人3 792名为调查对象,测定血压、血脂、血糖和肝功能等生化检测指标,并分析不同GGT水平人群的各指标的变化情况,了解不同GGT水平和BMI水平人群的MS患病率及不同GGT水平人群MS患病的比值比。结果男女性人群的BMI、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)和尿酸(UA)水平均随GGT水平的增加而上升(P趋势<0.01)。男女性GGT水平与BMI水平之间均存在交互作用(P交互作用<0.01),导致患MS。男女性患MS的危险性均随着GGT水平的增加呈上升趋势,差异有统计学意义(P<0.01),甚至调整年龄、UA、TC、TG、LDL-C和HDL-C后仍出现上升趋势,差异有统计学意义(P<0.01)。结论 GGT水平升高是MS的独立危险因素,可应用于MS的预测和筛检,为临床诊断治疗提供依据。
Objective To investigate the correlation between glutamyl transpeptidase (GGT) level and metabolic syndrome (MS), and to provide a basis for clinical diagnosis. Methods From March 2011 to February 2012, 3 792 adults aged 20 years and above who were in physical examination in the Physical Examination Department of Yanbian University Affiliated Hospital were enrolled in this study. The biochemical indexes such as blood pressure, blood lipid, blood glucose and liver function were measured and analyzed Different GGT levels of the various indicators of the changes in patients with different levels of GGT and BMI MS prevalence of people with different levels of GGT MS odds ratio. Results The BMI, SBP, DBP, TC, TG, HDL-C, FPG and uric acid (UA) increased with the increase of GGT level (P trend <0.01). There was an interaction between male and female GGT levels and BMI (P <0.01), leading to MS. The risk of MS in both men and women increased with the increase of GGT level, with statistical significance (P <0.01), even after adjusting for age, UA, TC, TG, LDL-C and HDL-C Trend, the difference was statistically significant (P <0.01). Conclusion The elevated GGT level is an independent risk factor for MS and can be used in the prediction and screening of MS, providing the basis for clinical diagnosis and treatment.