采用精子计数，精子活动率，精子形态学指标，观察了槟榔水提取液对雄性小鼠精子的影响。结果发现在３．７５ｇ／ｋｇ．ｂｗ剂量时，能使小鼠精子数量显著减少（ｔ＝１．８１１６，Ｐ＜０．０５）；在７．５０ｇ／ｋｇ．ｂｗ、１５００ｇ／ｋｇ．ｂｗ时，精子活动率明显降低（Ｕ值分别为２．８１４２、３．８９６６，Ｐ＜０．０１）；在剂量７．５０ｇ／ｋｇ．ｂｗ、３．７５０ｇ／ｋｇ．ｂｗ时，精子畸形率明显升高（χ２值分别为２２．８８３７、５９．５０，Ｐ＜０．０１）；且以无钩、不定形与胖头增加为主。提示槟榔对雄性小鼠生殖功能可能造成一定影响 Using sperm counts, sperm motility, and sperm morphological indicators, the effects of water extract of betel nut on sperm of male mice were observed. The result was found at 3.75 g/kg. At the bw dose, the number of spermatozoa in the mice was significantly reduced (t=1.8116, P<0.05); at 7.50 g/kg. Bw, 1500g/kg. At bw, the sperm activity rate was significantly reduced (U values ​​were 2.8142,3.8966, P<0.01); at a dose of 7.50 g/kg. Bw, 3.750g/kg. At bw, the sperm deformity rate was significantly increased (χ2 values ​​were 22.8837, 59.50, P<0.01), and the increase was mainly in the absence of hooks, indeterminate shapes, and fat heads. Prompt that betel nut may affect the reproductive function of male mice