我国生产的左旋18-甲基炔诺酮的孕素活性是否与消旋体呈倍效关系,这是临床使用复方18-甲基炔诺酮避孕丸配方时的依据。本工作采用了致大鼠蜕膜化作用,维持大鼠妊娠作用以及Clauberg试验三种检测孕素活性的方法,比较了左旋18-甲基炔诺酮与消旋18-甲基炔诺酮的孕素活性。用三种实验方法所得实验结果皆提示,两种18-甲基炔诺酮的孕素活性均强于孕酮,左旋18-甲基 China’s production of levonor 18-norgestrel progestin activity and racemic showed a multiple effect relationship, which is the clinical use of compound 18-norgestrel pill formulation basis. In this work, we used a method of rat decidualization to maintain the pregnancy effect of the rats and Clauberg test three methods of detection of progesterone activity. The effects of 18-norgestrel and racemic 18-norgestrel were compared Progestin activity. The experimental results obtained with the three experimental methods all suggest that the progestin activities of both 18-norgestrel are stronger than that of progesterone and levonor 18-methyl