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本实验以可移植性小鼠前胃鳞癌为肿瘤模型,进行不同方式的超分割实验性治疗,结果表明多分割组每日两次照射,每次200rad,总量6000rad时肿瘤控制最好,死亡率最低,平均存活时间最长。其优越性与放射生物学的修复、再增殖、再分布、再氧合密切相关。超分割可以缩短总治疗时间,提高肿瘤控制率、而死亡率低的特点,并较高LET、高压氧、高温、药物增敏剂的应用简便易行,便于临床推广使用。
In this experiment, transplantable mouse prodromal squamous carcinoma was used as a tumor model to perform different methods of hyperfractionated experimental treatment. The results showed that the multi-fractionated group irradiated twice daily, each time 200rad, and the total tumor volume was 6000rad. The lowest mortality rate, the longest average survival time. Its superiority is closely related to the repair, reproliferation, redistribution and reoxygenation of radiobiology. Hyperfractionation can shorten the total treatment time, improve the tumor control rate, and the characteristics of low mortality, and the application of high LET, hyperbaric oxygen, high temperature, drug sensitizer is simple and easy to implement, and is easy to use in clinical promotion.