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清华大学医学院祁海教授课题组揭示了人体免疫细胞逐步增高抗体亲和力的新机制,阐明了重要免疫疾病相关分子ICOSL(诱发性共刺激分子)在此过程中的决定性作用,为改善抗病毒抗体疫苗,特别是研发更有针对性的“靶点”中和抗体疫苗开辟了潜在新方向。英国《自然》杂志于北京时间16日凌晨两点在线发表了相关论文。抗体是人类抵抗病毒感染的最重要的免疫机制之一。“保护性抗体不但要能识别病的特征(抗原),还要紧密结合(亲和力)正确的’靶点’抗原才可能有效中和病毒。”祁海说,“以目前正在流行的埃博拉病毒、艾滋病病毒为例,通过疫苗诱导机体产生保护性抗体是最可能有效控制感染
Professor QI Hai from Tsinghua University School of Medicine revealed a new mechanism by which human immune cells gradually increase antibody affinity and elucidated the decisive role of ICOSL (induced costimulatory molecule), an important immune disease-related molecule, in this process. In order to improve the anti-virus antibody Vaccines, and in particular the development of more targeted ”target“ neutralizing antibody vaccines, open up new potential directions. British ”Nature“ magazine published online relevant papers at 2:00 on the 16th Beijing time. Antibodies are one of the most important immune mechanisms in human resistance to viral infections. ”Protective antibodies not only recognize the disease’s signature (antigen), but also bind closely to (the affinity) the correct ’target’ antigen to effectively neutralize the virus.“ Qi said, ”is currently prevalent Ebola virus, HIV, for example, the vaccine induced by the body to produce protective antibodies is the most effective control of infection