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很久以来,人们认为胃食道反流与许多呼吸系统疾病,特别与哮喘有关,之间关系可能有多种不同机制。首先,酸反流进入食道可产生气管收缩,食道的酸受体可激发反流性支气管痉挛,的确在另一部分胃肠道,反流性食道炎可使酸受体对局部酸作用更具敏感性,这可解释不同受试者有不同敏感性。酸受体受迷走神经支配。这一机制至少使部分患者产生支气管收缩,但收缩程度轻微,不可能单独致病。新近认为,食道内酸刺激和其他刺激相互作用产生支气管收
For a long time, people think that gastro-oesophageal reflux may be linked to many respiratory diseases, especially asthma, and there may be many different mechanisms. First, the acid reflux into the esophagus can produce tracheal contraction, esophageal acid receptors can stimulate reflux bronchospasm, indeed in the other part of the gastrointestinal tract, reflux esophagitis can make acid receptors more sensitive to the role of local acid This may explain the different sensitivities of different subjects. Acid receptors are subject to the vagus nerve. This mechanism at least some patients produce bronchoconstriction, but a slight degree of contraction, it is impossible to cause disease alone. Recently that the esophageal acid stimulation and other stimuli produce bronchial closure