应用 3因素 5水平的均匀设计方法 ,研究了 β 环糊精对冰片的包合作用 .通过对包合物收率和包合率这二个指标的比较 ,筛选优化出冰片 β 环糊精包合物的最佳制备条件 ,在此条件下 ,分别采用 4种不同的包合方法制备冰片 β 环糊精包合物 ,结果以球磨法为最好 ,所得包合物的包合率和收率分别为 99 2 1%和 98 10 % The inclusion effect of β-cyclodextrin on borneol was studied by the uniform design method of 3-factor-5 level. By comparing the two indexes of inclusion compound yield and inclusion rate, we selected and optimized borneol β-cyclodextrin package The optimum preparation conditions were as follows: under different conditions, four different inclusion methods were used to prepare borneol β cyclodextrin inclusion complex. The best results were obtained by ball milling method. Rates were 99 2 1% and 98 10%