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目的 观察雷公藤多甙对小肠移植急性排斥反应的治疗作用。方法 选用近交系大鼠Ｆ３４４／Ｎ 和Ｗｉｓｔａｒ／Ａ 进行全小肠异位移植，实验分３ 组，第１ 组：非治疗对照组（Ｆ３４４Ｗｉｓｔａｒ）；第２组：ＣｓＡ 治疗对照组［Ｆ３４４Ｗｉｓｔａｒ＋ Ｃｓａ（６ｍｇ，肌肉注射）］ ；第３ 组：雷公藤多甙治疗组［Ｆ３４４Ｗｉｓｔａｒ＋雷公藤多甙（５０ ｍｇ／ｋｇ，灌胃）］。观察动物存活及一般状况，并于术后第３ 、５ 、７ｄ 取移植肠标本进行病理学检查。结果 第１ 组大鼠存活时间（６．８３ ±０ ．４１） ｄ，第３ 组大鼠存活时间为（８．００ ±０ ．６３） ｄ，二者间有极显著差异（Ｐ＜ ０ ．０１），第２ 组大鼠存活均超过１０ ｄ，并于１０ ｄ 时处死。病理检查显示第１ 组术后第３ ｄ 发生轻度排斥，第５ｄ 发生中度排斥，第７ｄ 发生重度排斥；第２ 组除部分标本在术后第５ 、７ｄ 发生轻度排斥外，无排斥征象；第３ 组与第１ 组改变相似，但排斥的病理改变发生较晚、较轻。结论 对小肠移植急性排斥的治疗，在５０ ｍｇ／ｋｇ 剂量水平上单独使用雷公藤多甙，其免疫抑制作用是明确的，但疗效有限。
Objective To observe the therapeutic effects of Tripterygium wilfordii on acute rejection of small bowel transplantation. METHODS: Inbred rat F344/N and Wistar/A were used for total intestinal heterotopic transplantation. The experiment was divided into 3 groups: Group 1: non-treated control group (F344-Wistar); Group 2: CsA-treated control group [F344 _ Wistar + Csa (6 mg, intramuscular injection); Group 3: Tripterygium wilfordii treatment group [F344 Wistar + Tripterygium wilfordii (50 mg/kg, gavage)]. Animals were observed for survival and general conditions, and transplanted intestinal specimens were taken for pathological examination on the 3rd, 5th and 7th days after operation. Results The survival time of group 1 rats was (6.83 ± 0.41) days, and the survival time of group 3 rats was (8.00 ± 0.63) days. There was a significant difference between the two groups (P < 0. 01) Rats in group 2 survived more than 10 days and were sacrificed at 10 days. Pathological examination showed mild rejection on the 3rd day after operation in the first group, moderate rejection on the 5th day, and severe rejection on the 7th day. The second group had no rejection except for mild rejection on the 5th and 7th days after operation. Signs; Group 3 and Group 1 were similarly changed, but rejection of pathological changes occurred later and lighter. Conclusion For the treatment of acute rejection of small bowel transplantation, triptolide is used alone at a dose of 50 mg/kg. The immunosuppressive effect is clear but the efficacy is limited.