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三七[Panax notoginseng(Burk)F.H Chen]系五加科人参属植物,中医用于止血、止痛、散瘀、消肿。1972年以来陆续报告三七增加冠脉流量、降低动脉血压、减慢心率和降低心肌耗氧量。我省一些临床单位也报道三七对冠心病有一定疗效。我省药物研究所由三七绒根中提得76017号提出物(以下简称17号),我们用它作了下列药理实验。1.离体豚鼠心脏灌流实验:按 Langendorff 氏法,采用循环恒温装置,以 Locke 液灌流。搏动心脏共14个标本,1:20,000的17号使冠脉流量平均增加84.04%(P<0.01),同时见心搏增强,而心率改变无
Panax notoginseng (Burk) F.H Chen is a plant of the genus Panax ginseng. Chinese medicine is used to stop bleeding, relieve pain, spread phlegm, and reduce swelling. Since 1972, Panax pseudoginseng has been reported to increase coronary flow, reduce arterial blood pressure, slow heart rate, and reduce myocardial oxygen consumption. Some clinical units in our province have also reported that Sanqi has a certain effect on coronary heart disease. The Provincial Institute of Materia Medica was proposed by No. 76017 of Sanqi Ronggen (hereinafter referred to as No.17), and we used it for the following pharmacological experiments. 1. In vitro guinea pig heart perfusion experiments: Perfusion was performed using Locke’s solution according to the Langendorff’s method using a circulating thermostat. A total of 14 samples were pulsated in the heart. Coronary flow was increased by an average of 84.04% in the 1:20,000 No. 17 (P<0.01). At the same time, the increase in heart rate was seen, while no change in heart rate was observed.