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目的：研究乙肝病毒与胃十二指肠粘膜病变及血清HBVM的关系。方法：应用HE染色、SP兔疫组化法检测63例乙肝病人胃十二指肠粘膜的HBsAg、HBcAg；应用酶标法检测其血清HBsAg、HBcAg，地高辛探针法检测HBV－DNA。结果：63例乙肝病人胃十二指肠粘膜均有不同程度的病理改变，以慢性浅表性胃炎多见，其次为溃疡病；胃十二指肠粘膜单项HB－sAg阳性率约31．7％，单项HBcAg阳性率约22．2％，一项以上阳性率约42．9％；胃十二指肠粘膜HBVM与病变程度有关，与血清相应的HBVM、HBV-DNA无关。结论：HBV可侵犯胃十二指肠粘膜，可能发生原位复制引发病理损伤。胃十二指肠粘膜HBsAg、HBcAg检测可作为判断HBV在体内复制、分布状态的新指标。
Objective: To study the relationship between hepatitis B virus (HBV) and gastric mucosal lesions and serum HBVM. Methods: Hematoxylin and eosin (HE) and SP immunohistochemistry were used to detect HBsAg and HBcAg in gastric mucosa of 63 cases of hepatitis B patients. HBsAg and HBcAg were detected by enzyme-linked immunosorbent assay (ELISA) and digoxigenin probe method. Results: The pathological changes of gastroduodenal mucosa in 63 patients with hepatitis B were observed in varying degrees, with chronic superficial gastritis more common, followed by ulcer disease. The positive rate of HBsAg in gastric mucosa was about 31.7 %. The positive rate of single HBcAg was about 22.2% and the positive rate of one was about 42.9%. The gastroduodenal mucosa HBVM was related to the degree of lesion, but not to the serum HBVM and HBV-DNA. Conclusion: HBV can invade gastroduodenal mucosa and may cause pathological damage in situ. Gastric and duodenal mucosa HBsAg, HBcAg detection can be used as a new indicator of HBV replication in vivo distribution status.