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流行病学研究没有证实卒中风险与高胆固醇血症之间有明确的关系,但是他汀类药物的临床试验已经证实其可以降低卒中的发生率,特别是对于那些确诊的冠状动脉疾病患者。流行病学和临床研究的不一致提示:高胆固醇血症确实是卒中的一项危险因素,而流行病学研究未能检测出两者之间的关系;或者他汀类药物具有的其他特性使其能够在卒中预防方面发挥作用。在有关的血脂研究中这些作用被称为“多效性”,主要表现在他汀类药物对内皮功能、炎症、血栓形成、血小板稳定性、免疫调节有作用。然而,还不清楚的是,他汀类药物有效预防卒中的作用机制、他汀类药物在卒中一级预防中的地位以及他汀类药物在大脑免疫系统调节中的作用。
Epidemiologic studies did not confirm a clear relationship between stroke risk and hypercholesterolemia, but statin clinical trials have shown it can reduce the incidence of stroke, especially in those diagnosed with coronary artery disease. Inconsistencies between epidemiological and clinical studies suggest that hypercholesterolemia is indeed a risk factor for stroke and that epidemiological studies fail to detect the relationship between the two; or that the statin has other properties that enable it Play a role in stroke prevention. These effects are referred to as “pleiotropic” in the relevant lipid study, mainly in the role of statins in endothelial function, inflammation, thrombosis, platelet stability, and immune regulation. However, it is not yet clear what the mechanism of action of statins in preventing stroke, the role of statins in primary prevention of stroke, and the role of statins in the regulation of the immune system of the brain.