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目的:探讨代谢正常肥胖(Metabolically healthy obese,MHO)个体与非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)发生的相关性。方法:选择2006年4月～2010年1月来湖南省人民医院体检中心体检人群共4076例,排除过量饮酒者、乙肝标志物阳性者及相关资料不全者共2830例纳入本研究。其中1367例在1～3年后再次体检。记录受检者身高、体重、血压、血脂、空腹血糖、腹部B超结果。NAFLD采用2010年中华医学会肝病学分会诊断标准中影像学诊断定义,行腹部B超检查进行诊断。结果:1.我院体检人群中MHO合并NAFLD者占51.34%,明显高于正常对照组(P=0.000),MHO组发生NAFLD的OR值为19.967(95%CI,12.646-31.533;P=0.000)。2.随访1～3年后,MHO中NAFLD发病率高于正常对照组(44.44%vs 7.02%,OR=10.600,95%CI,4.873-23.058;P=0.000)。结论:MHO个体合并NAFLD比例较正常对照者升高,MHO个体增加NAFLD患病风险。
Objective: To investigate the correlation between Mab individuals and nonalcoholic fatty liver disease (NAFLD). Methods: From April 2006 to January 2010, a total of 4076 cases of physical examination in Hunan Provincial People ’s Hospital were enrolled in this study. A total of 2830 cases with excessive alcohol consumption, positive HBsAg markers and related incomplete data were included in this study. Of these, 1367 were examined again 1-3 years later. Record the subject’s height, weight, blood pressure, blood lipids, fasting blood glucose, abdominal B-ultrasound results. NAFLD 2010 diagnostic criteria by the Chinese Medical Association of Liver Diseases Diagnostic Imaging definition, abdominal B-ultrasound diagnosis. Results: 1. The MHO patients with NAFLD accounted for 51.34% of the physical examination population in our hospital, which was significantly higher than that of the normal control group (P = 0.000). The OR of NAFLD in MHO group was 19.967 (95% CI, 12.646-31.533; P = 0.000 ). The incidence of NAFLD in MHO was higher than that in the control group (44.44% vs 7.02%, OR = 10.600, 95% CI, 4.873-23.058; P = 0.000) after 1 to 3 years of follow-up. Conclusion: The proportion of MHO individuals with NAFLD is higher than that of normal controls, and MHO individuals increase the risk of NAFLD.