血管内皮细胞产生的前列腺环素(PGI_2)具有极强的抑制血小板凝集作用,因此,不可忽视它与动脉硬化性病变的关系。最近,日本国立医院医疗中心临床研究部的川上正舒科研小组报告,一般认为是肿瘤特异性物质的肿瘤坏死因子(TNF)可促进前列腺环素的产生。川上指出:TNF一方面可作为动脉硬化的触发物,另一方面又可促进前列腺环素的产生,作为动脉硬化抑制因子而发挥作用。 Prostacyclin (PGI_2) produced by vascular endothelial cells has a very strong inhibitory effect on platelet aggregation, therefore, its relationship with arteriosclerotic lesions can not be neglected. Recently, Masatoshi Kawakami, a clinical research arm of Japan’s National Hospital Medical Center, reported that tumor necrosis factor (TNF), a tumor-specific substance, is believed to promote prostacyclin production. Kawakami pointed out: TNF on the one hand can be used as a trigger of arteriosclerosis, on the other hand can promote prostacyclin production, as atherosclerosis inhibitory factor and play a role.