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应用心钠素快速放射免疫分析法观测了52例慢性肺心病患者血浆心钠素浓度变化,结果发现,单纯慢性肺心病组血浆心钠素浓度为93.12±7.2pmol/L,较正常对照组、冠心病组及慢性肺心病合并冠心病组明显降低(P<0.001)。慢性肺心病患者血浆心钠素浓度似与动脉血二氧化碳分压呈负相关趋势,但统计学上无显著意义(r=-0.521,P>0.05),与动脉血氧分压亦无相关性(r=0.185,P>0.05)。并对其临床意义进行了初步探讨。
Application of rapid atrial natriuretic peptide radioimmunoassay in patients with chronic pulmonary heart disease in 52 cases of atrial natriuretic peptide concentration changes, found that chronic pulmonary heart disease plasma atrial natriuretic peptide concentration of 93.12 ± 7.2pmol / L, compared with the normal control group, Coronary heart disease group and chronic pulmonary heart disease with coronary heart disease group was significantly lower (P <0.001). Plasma concentrations of atrial natriuretic peptide in patients with chronic cor pulmonale were negatively correlated with arterial carbon dioxide partial pressure, but there was no statistical significance (r = -0.521, P> 0.05) and no correlation with arterial partial pressure of oxygen r = 0.185, P> 0.05). And the clinical significance of a preliminary study.