恶性肿瘤是导致人类发病和死亡的主要原因之一。恶性肿瘤的病因至今尚未完全明确,但是国内外众多的研究证实其与血管内皮细胞生长因子(VEGFs)家族有关,VEGFs是从牛垂体滤泡星形细胞体外培养液中纯化出来的。在受到恶性肿瘤侵袭和转移的组织中,通过免疫组织化学方法可以检测到这些因子的表达,为恶性肿瘤的筛选、预测和诊疗提供了新的思路。 Malignancy is one of the major causes of morbidity and mortality in humans. Although the etiology of malignant tumors is not yet completely understood, many researches at home and abroad have confirmed that VEGFs are related to the VEGFs family. VEGFs are purified from bovine pituitary astrocytes in vitro. The expression of these factors can be detected by immunohistochemistry in the tissues affected by malignant tumor invasion and metastasis, which provides a new idea for the screening, prediction and diagnosis of malignant tumors.