论文部分内容阅读
目的观察中药保留灌肠联合美沙拉嗪口服治疗溃疡性结肠炎的临床疗效。方法将2010年1月至2015年12月消化内科收治住院的163例溃疡性结肠炎患者分为对照组和观察组。两组均给予美沙拉嗪口服及支持对症治疗,观察组在以上基础上联合应用中药保留灌肠,疗程均为4周。记录两组患者临床症状改善情况及肠镜变化,比较两组治疗效果。结果治疗后两组患者腹痛、腹泻及脓血便均明显减少,且观察组优于对照组(P均<0.05),观察组临床总有效率高于对照组(95.12%vs 71.60%,χ2=16.306,P<0.01);肠镜疗效方面,观察组总有效率为87.80%,对照组为69.14%,两组比较差异有统计学意义(χ2=8.423,P<0.01)。结论中药保留灌肠联合美沙拉嗪治疗轻、中度溃疡性结肠炎疗效优于单用美沙拉嗪治疗,且无明显不良反应。
Objective To observe the clinical efficacy of traditional Chinese medicine enema retention enema combined with mesalazine for the treatment of ulcerative colitis. Methods 163 patients with ulcerative colitis admitted to hospital from January 2010 to December 2015 were divided into control group and observation group. Both groups were given mesalazine oral and support symptomatic treatment, the observation group based on the combination of traditional Chinese medicine retention enema, treatment were 4 weeks. The improvement of clinical symptoms and enteroscopy in the two groups were recorded, and the treatment effect was compared between the two groups. Results After treatment, abdominal pain, diarrhea and pus and blood stool were significantly decreased in both groups, and the observation group was superior to the control group (P <0.05). The total effective rate in the observation group was significantly higher than that in the control group (95.12% vs 71.60%, χ2 = 16.306 , P <0.01). The total effective rate was 87.80% in the observation group and 69.14% in the control group. The difference between the two groups was statistically significant (χ2 = 8.423, P <0.01). Conclusion Chinese medicine retention enema combined with mesalazine for the treatment of mild to moderate ulcerative colitis is more effective than mesalazine alone, with no obvious adverse reactions.