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巨细胞病毒是引起免疫功能低下宿主肺部感染最常见的病原之一,在临床上起病急、进展快,如不能及时诊断和干预,往往会在短期内发展为急性肺损伤甚或急性呼吸窘迫综合征及多器官功能衰竭,病死率高,预后差。实验室病毒学检测对早期诊断具有重要作用。在治疗上除了对症支持、保证氧合外,早期应用更昔洛韦抗病毒联合静脉丙种球蛋白,在一定程度上可改善预后,降低病死率。除非有明确细菌感染的指征或有创呼吸治疗,一般不主张给予联合抗生素治疗,以避免治疗进一步复杂化。
Cytomegalovirus is one of the most common pathogens causing lung infections in immunocompromised hosts. It is clinically acute and has rapid progression. If not diagnosed and timely, cytomegalovirus often develops acute lung injury or even acute respiratory distress in the short term Syndrome and multiple organ failure, high mortality, poor prognosis. Laboratory virological testing plays an important role in early diagnosis. In addition to the symptomatic treatment support, to ensure oxygenation, the early application of ganciclovir antiviral intravenous gamma globulin, to a certain extent, can improve the prognosis and reduce mortality. Unless there is a clear indication of bacterial infection or invasive respiratory therapy, it is generally not recommended to give the combination of antibiotics to prevent further complications.