In this study,ultrasonic backscattering signals in cancellous bones were obtained by finite difierence time domain(FDTD)simulations,and the effect of trabecular material properties on these signals was analyzed.The backscatter coefficient(BSC)and integrated backscatter coefficient(IBC)were numerically investigated for varying trabecular bone material properties,including density,Lame coefficients,viscosities,and resistance coefficients.The results show that the BSC is a complex function of trabecular bone density.and the IBC increases as density increases.The BSC and IBC increase with the first and second Lamd coefficients.While not very sensitive to the second viscosity of the trabeculae.the BSC and IBC decrease as the first viscosity and resistance coefficients increase.The results demonstrate that,in addition to bone mineral density(BMD)and microarchitecture,trabecular material properties significantly influence ultrasonic backscattering signals in cancellous bones.This research furthers the understanding of ultrasonic backscattering in cancellous bones and the characterization of cancellous bone status. In this study, ultrasonic backscattering signals in cancellous bones were obtained by finite difierence time domain (FDTD) simulations, and the effect of trabecular material properties on these signals was analyzed. Backscatter coefficient (BSC) and integrated backscatter coefficient (IBC) were numerically investigated for varying trabecular bone material properties, including density, Lame coefficients, viscosities, and resistance coefficients. The results show that the BSC is a complex function of trabecular bone density. and the IBC increases as density increases. The BSC and IBC increase with the first and second Lamd coefficients. Whilst not sensitive to the second viscosity of the trabeculae. the BSC and IBC decrease as the first viscosity and resistance coefficients increase. results demonstrate that, in addition to bone mineral density (BMD) and microarchitecture, trabecular material properties significant influence ultrasonic backscattering signals in cancellous bones.This research fur thers the understanding of ultrasonic backscattering in cancellous bones and the characterization of cancellous bone status.