研究两种具有光学活性的杂二齿螯合物(1S,2S)-2-{甲基[(R)-3甲基-2-丁基]氨基)-1-苯基-1-丙醇和(1R,2R)-2-氨基-1-苯基-1-丙醇的合成方法。分别以麻黄碱和苯甲醛为原料通过成环、还原等方法得到光学活性单一的目标化合物,其结构通过~1H NMR确认。设计的合成路线有收率高、反应条件相对温和、生成物光学活性单一等特点。 Two optically active bismuth chelates (1S, 2S) -2- {methyl [(R) -3methyl- 2 -butyl] amino) -1-phenyl- 1-propanol and (1R, 2R) -2-amino-1-phenyl-1-propanol. Respectively, ephedrine and benzaldehyde as raw materials through the ring, reduction and other methods to obtain a single optically active compound, its structure confirmed by ~ 1H NMR. The synthetic route of the design has the advantages of high yield, relatively mild reaction conditions and single product activity.