1969年报道多氯联苯(PCBs)中毒的母亲的胎儿和出生后母乳喂养的婴儿出现某些 PCBs中毒的症状,说明PCBs可通过胎盘和乳汁从母亲向胎儿和婴儿转移。不同的PCBs的生物活性差异很大,为了研究它们向胎儿和子代的转移是否也随着结构而异,作者以7种不同的PCBs经口给予妊娠前和妊娠期小鼠来研究这种可能性。实验用10周龄ddN系雌性小鼠 Some PCBs poisoning was reported in 1969 in mothers with PCBs poisoning and in breastfed infants after birth, indicating that PCBs can be transferred from mother to fetus and infant via the placenta and milk. The biological activity of different PCBs varies greatly. To investigate whether their transfer to the fetus and offspring also varies with structure, the authors investigated the possibility of orally administering pre-pregnancy and post-pregnancy mice with seven different PCBs . Experimental 10-week-old ddN female mice