雄激素受体(AR)的病理生理变化及遗传性缺陷与多种临床疾病有关,因此,建立AR的临床研究方法很有必要。外阴部皮肤的成纤维细胞是雄激素的靶细胞,该部皮肤取材方便,其培养的成纤维细胞因能在体外传代,故可反复应用,是AR临床研究较为理想的材料。本实验以人工合成的雄激素—~3H-R1881为配体,在国内 Androgen receptor (AR) pathophysiological changes and genetic defects associated with a variety of clinical diseases, therefore, the establishment of AR clinical research methods are necessary. The genital skin fibroblasts are the target cells of the androgen. The skin of the part is easy to obtain and the cultured fibroblasts can be repeatedly used because they can be passaged in vitro. Therefore, it is an ideal material for AR clinical research. In this experiment, synthetic androgen - ~ 3H-R1881 as a ligand in the country