论文部分内容阅读
目的:初步分析非霍奇金淋巴瘤患者临床病理因素与预后的关系。方法:回顾性分析我院70例非霍奇金淋巴瘤患者的性别、年龄、ECOG评分、恶性程度、临床分期、最大肿瘤直径、结外受累部位数、有无B症状、LDH、β2微球蛋白、疗效及肿瘤进展时间(TTP)等。应用SAS8.2统计软件分析各临床病理因素与预后的关系。结果:单因素分析显示,年龄(P=0.040)、ECOG评分(P=0.032)、临床分期(P=0.033)、最大肿瘤直径(P=0.028)、结外受累部位数(P=0.000)、血清乳酸脱氢酶(LDH,P=0.041)和疗效(P=0.000)是影响TTP的单个因素。多因素分析显示,ECOG评分(P=0.046)、临床分期(P=0.035)、最大肿瘤直径(P=0.021)、结外受累部位数(P=0.007)和疗效(P=0.000)影响TTP的独立预后因素。结论:ECOG评分、临床分期、最大肿瘤直径、结外受累部位数、疗效等许多临床病理因素影响着患者的预后。
Objective: To analyze the relationship between clinicopathologic features and prognosis in patients with non-Hodgkin’s lymphoma. Methods: Retrospective analysis of 70 patients with non-Hodgkin’s lymphoma in our hospital sex, age, ECOG score, degree of malignancy, clinical stage, the largest tumor diameter, extranodal involvement sites, with or without B symptoms, LDH, β2 microspheres Protein, efficacy and tumor progression time (TTP). SAS8.2 statistical software was used to analyze the relationship between clinicopathological parameters and prognosis. Results: Univariate analysis showed that age (P = 0.040), ECOG score (P = 0.032), clinical stage (P = 0.033), maximum tumor diameter Serum lactate dehydrogenase (LDH, P = 0.041) and efficacy (P = 0.000) were single factors affecting TTP. Multivariate analysis showed that the number of TTP (P = 0.046), clinical stage (P = 0.035), maximum tumor diameter (P = 0.021), extranodal involvement (P = 0.007) Independent prognostic factors. Conclusion: There are many clinicopathological factors such as ECOG score, clinical stage, maximal tumor diameter, extranodal involvement site number, curative effect and so on, which affect the prognosis of patients.