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目的研究载银二氧化钛(Ag-TiO_2)抗菌涂层气管导管的抗真菌性能,并确定最合适的抗菌剂浓度,为后续试验提供依据。方法试验分为9组(5%组、2%组、1.5%组、1%组、0.8%组、0.6%组、0.2%组、常规导管组和空白组),采用菌液浸渍法测定各组对2株白色念珠菌(氟康唑敏感株和耐药株)的抑菌性能。结果 1%及以上浓度组均基本抑制了2株白色念珠菌的生长,抑菌率在90%以上;0.8%组对白色念珠菌有比较明显的抑制效果,抑菌率低于1%组又高于0.6%组,差异有统计学意义(P<0.05);常规导管组、0.6%组、0.2%组与空白组相比较,抑菌率差异有统计学意义(P<0.05)。结论本课题组研制的抗菌涂层气管导管具有明显的抗真菌性能,且对敏感和耐药菌株的抑制能力相似,Ag-TiO_2最佳浓度为1%。
Objective To study the antifungal properties of Ag-TiO 2 antimicrobial coated tracheal tube and to determine the most suitable concentration of antimicrobial agent for the follow-up test. Methods The experiment was divided into 9 groups (5% group, 2% group, 1.5% group, 1% group, 0.8% group, 0.6% group, 0.2% group, conventional catheter group and blank group) Antibacterial activity of two strains of Candida albicans (fluconazole sensitive and resistant strains). Results The growth of Candida albicans was basically inhibited in 1% and above concentration groups, with the antibacterial rate above 90%. 0.8% of the Candida albicans group had a significant inhibitory effect and the antibacterial rate below 1% The difference was statistically significant (P <0.05) between the 0.6% and 0.6% groups (P <0.05). Conclusion The antimicrobial-coated tracheal tube developed by our group has obvious anti-fungal properties and similar inhibitory ability to sensitive and resistant strains. The optimum concentration of Ag-TiO 2 is 1%.