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目的探讨非神经系统原发恶性肿瘤伴发急性脑梗死的临床特点、神经影像特点及治疗。方法收集2013年5月—2015年5月河北省唐山市人民医院收治的非神经系统原发恶性肿瘤伴发急性脑梗死患者与非肿瘤急性缺血性卒中患者的临床及神经影像学资料进行分析。结果单因素预后分析表明非神经系统原发恶性肿瘤患者并发脑梗死的影响因素有既往高血压病史(P<0.05),多因素预后分析表明肿瘤组血红蛋白、血小板计数、血栓两项、梗死病灶数为影响因素(P<0.05,P<0.01,P<0.05)。结论非神经系统原发恶性肿瘤伴发急性脑梗死的病因是多因素的,脑内多发性病灶为主要表现,血液高凝状态是血栓形成的可能发生机制,治疗应强调多因素、个体化。
Objective To investigate the clinical characteristics, neuroimaging characteristics and treatment of primary non-neuronal malignant tumor associated with acute cerebral infarction. Methods The clinical and neuroimaging data of patients with non-neuronal primary malignant tumor associated with acute cerebral infarction and non-tumor acute ischemic stroke who were admitted to Tangshan People’s Hospital of Hebei Province from May 2013 to May 2015 were collected. . Results The univariate analysis showed that the influencing factors of cerebral infarction in non-neurosurgical patients with primary malignant tumor had the history of previous hypertension (P <0.05). Multivariate prognostic analysis showed that there were significant differences in hemoglobin, platelet count, thrombosis, As the influencing factors (P <0.05, P <0.01, P <0.05). Conclusion The causes of acute cerebral infarction in non-neuronal primary malignant tumors are multifactorial. Multiple lesions in the brain are the main manifestations. The hypercoagulable state of blood is the possible mechanism of thrombosis. Treatment should emphasize multifactorial and individualized treatment.