激素类抗肿瘤药物包括雌激素、孕激素、雄激素及其拮抗剂,其作用机制决定了此类药物不仅可以在抗肿瘤治疗中发挥作用,也可以在其他一些激素相关的疾病中达到良好的治疗效果,而药品说明书往往落后于临床实际,从而导致了一些超说明书用药情况的发生。该文就激素类抗肿瘤药物在临床应用已较为广泛的促排卵治疗、乳腺增生、卵巢保护、中枢性性早熟等的超说明书用药情况进行了综述。 Hormonal anti-cancer drugs, including estrogen, progesterone, androgen and its antagonist, its mechanism of action determines that these drugs can not only play a role in anti-tumor therapy, but also in other hormone-related diseases to achieve good Treatment effect, and drug manuals often lag behind in clinical practice, resulting in some super manual medication situation. This article reviews the clinical application of hormonal antitumor drugs in ovarian hyperstimulation, breast hyperplasia, ovarian protection, central precocious puberty and so on.