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目的 用太原地区健康女性胫骨定量超声骨量 (QUS)的健康参考值 ,探讨诊断骨质疏松症的诊断标准及骨折阈值。方法 对太原地区的健康女性 1736例 (9～ 83岁 )和骨质疏松女性 187例 (4 2～80岁 ) ;其中骨折患者 6 7例 ,测定胫骨定量超声骨量值。结果 健康女性 30岁以前胫骨 SOS值随年龄的增加而升高 ;30～ 4 0岁达到峰值 ,4 0岁以后胫骨 SOS值开始下降 ;绝经后胫骨 SOS值明显降低 ,与绝经时间呈负相关 (r=0 .56 ) ;骨折患者胫骨 SOS值明显低于健康女性 (P<0 .0 1) ;也低于骨质疏松组患者 (P<0 .0 5)。以 2 0～ 4 0岁健康女性胫骨 SOS均值减 2 .0及 2 .5标准差 ,分别得出各自的界限值(36 94 .837m/ s和 36 6 7.2 4 3m/ s) ,187例女性骨质疏松患者中 171例 (91.4 % )胫骨 SOS值低于此界限值。6 7例女性骨折患者中 6 4例 (95.5% )胫骨 SOS值低于此界限值。结论 健康女性胫骨 SOS值 2 .0标准差界限值可作为女性骨质疏松症的诊断标准 ;2 .5标准差 SOS界限值可作为女性骨质疏松症的骨折危险阈值。
Objective To evaluate the diagnostic criteria and fracture threshold of quantitative femoral ultrasound (QUS) in female healthy tibia in Taiyuan area. Methods A total of 1736 healthy women (aged 9-83 years) and 187 osteoporotic women (aged 4-2-80 years) in Taiyuan were included in this study. Totally 67 patients with fractures were involved in this study. Results Before the age of 30, the female SOS value of tibia increased with age. The peak value was reached at 30 ~ 40 years old. The SOS value of tibia began to decline after 40 years old. The SOS value of tibia decreased significantly after menopause and was negatively correlated with menopause time r = 0.56). The SOS value of tibia in fractured patients was significantly lower than that in healthy women (P <0.01) and lower than that in osteoporosis patients (P <0.05). The mean values of SOS in twentyear females from 20 to 40 years old were reduced by 2.0 and 2.5 standard deviations to get the respective limits (36 94 .837 m / s and 36 6 7.2 4 3 m / s), 187 women 171 patients (91.4%) with osteoporosis had tibial SOS values below this threshold. Sixty-four (95.5%) of the 67 female fractures had tibial SOS values below this threshold. Conclusions The standard deviation of SOS value of 2.0 for healthy female tibia can be used as the diagnostic criteria for female osteoporosis. The standard deviation SOS threshold value can be used as the fracture risk threshold for female osteoporosis.