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目的:探讨C-反应蛋白(CRP)与儿童反复呼吸道感染(recurrent respiratory infection,RRI)的关系及其临床意义。方法:选择新疆医科大学第五附属医院2009年10月～2010年10月明确诊断儿童反复呼吸道感染患者146例,采用透射免疫比浊法进行C-反应蛋白检测,检测64例急性细菌性呼吸道感染患儿(细菌感染组)、82例急性病毒性呼吸道感染患儿(病毒感染组)的血清CRP水平,并与35例正常小儿进行对比。结果:细菌感染组血清CRP明显增高,与病毒感染组和正常对照组比较差异有统计学意义(P<0.01),而病毒感染组与对照组CRP比较差异无统计学意义(P>0.05);康复前后细菌感染组CRP差异有统计学意义(P<0.01),而病毒感染组差异无统计学意义(P>0.05)。结论:检测患儿血清CRP水平可作为儿童呼吸道感染疾病中鉴别细菌、病毒感染的可靠指标,对抗生素的使用和临床疗效的判定均具有重要价值,值得临床参考应用。
Objective: To investigate the relationship between C-reactive protein (CRP) and recurrent respiratory infection (RRI) in children and its clinical significance. Methods: A total of 146 patients with recurrent respiratory tract infections in children were diagnosed in the Fifth Affiliated Hospital of Xinjiang Medical University from October 2009 to October 2010. C-reactive protein was detected by transmission immunoassay, and 64 cases of acute bacterial respiratory tract infection Serum CRP level in children (bacterial infection group) and 82 children with acute viral respiratory infection (virus infected group) were compared with 35 normal children. Results: The serum CRP in bacterial infection group was significantly higher than that in virus infection group and normal control group (P <0.01), while there was no significant difference in CRP between viral infection group and control group (P> 0.05). Before and after rehabilitation, there was a significant difference in CRP between bacterial infection groups (P <0.01), but there was no significant difference between virus infection groups (P> 0.05). Conclusion: The detection of serum CRP levels in children can be used as a reliable indicator of bacterial and viral infection in children with respiratory infections. The use of antibiotics and the determination of clinical efficacy are of great value and worthy of clinical reference.