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目的探讨疣状表皮痣(verrucous epidermal nevi,VEN)的临床病理特点,提高对本病的认识。方法回顾性分析62例VEN患者的临床和组织病理资料。结果患者发病年龄从出生至29岁,62例患者中局限型29例(46.77%),系统型19例(30.65%),炎症性线状型(ILVEN)14例(22.58%)。局限型和系统型皮损表现为疣状丘疹或斑块,炎症性线状型表现为线状红色瘙痒性斑块。皮损组织病理主要表现为:角化过度、棘层肥厚、乳头瘤样增生和皮突延长,多数病例伴颗粒层增厚,有的病例伴角化不全、表皮松解性角化过度、基底层色素增加以及真皮浅层血管周围淋巴细胞和组织细胞轻度至中度浸润。结论 VEN多发生于出生时和婴儿期,但婴儿期后发病并不少见,且以局限型最为多见。本病皮损具有特征性,组织病理有助于鉴别诊断。
Objective To investigate the clinicopathological features of verrucous epidermal nevus (VEN) and to improve its understanding of the disease. Methods The clinical and histopathological data of 62 VEN patients were retrospectively analyzed. Results The age of patients was 29 years old from birth to 29 years old. Among 62 patients, 29 cases were localized (46.77%), 19 cases were systemic (30.65%) and 14 cases were inflammatory cytotype (ILVEN) (22.58%). The localized and systemic lesions showed verrucous papules or plaques and the inflammatory linear pattern showed linear red pruritus plaques. Histopathology showed mainly as follows: hyperkeratosis, acanthosis, papillomatous hyperplasia and lenticel lengthening, the majority of cases with granular layer thickening, and some cases with parakeratosis, epidermolysis hyperkeratosis, base Subchlanophores increase as well as mild to moderate infiltration of perivascular lymphocytes and tissue cells in the dermis. Conclusions VEN mostly occurs at birth and in infancy, but it is not uncommon for infants to develop their disease after infancy and is most often seen as localized. Lesions of the disease is characteristic, histopathology contribute to the differential diagnosis.