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目的探讨氧化修饰低密度脂蛋白（ＯＸ－ＬＤＬ）与动脉粥样硬化性血栓性脑梗塞（ＡＴＣＩ）发生、发展的关系。方法应用酶联免疫吸附试验（ＥＬＩＳＡ）双抗夹心法检测了８３例ＡＴＣＩ患者血浆ＯＸ－ＬＤＬ含量变化。结果（１）ＡＴＣＩ组血浆ＯＸ－ＬＤＬ水平显著高于正常对照组（Ｐ＜０．０１）；血浆ＯＸ－ＬＤＬ水平变化与病程有关，但与梗塞部位无关。（２）ＡＴＣＩ患者血浆ＯＸ－ＬＤＬ水平与血糖、血胆固醇呈正相关。结论ＯＸ－ＬＤＬ可能参与了ＡＴＣＩ的发生和发展过程。
Objective To investigate the relationship between the development of oxidized low density lipoprotein (OX-LDL) and the development of atherothrombotic cerebral infarction (ATCI). Methods The plasma levels of OX-LDL in 83 patients with ATCI were measured by enzyme linked immunosorbent assay (ELISA) double antibody sandwich method. Results (1) The level of plasma OX-LDL in ATCI group was significantly higher than that in normal control group (P <0.01). The change of plasma OX-LDL level was related to the course of disease, but not to the infarct site. (2) The level of plasma OX-LDL in patients with ATCI was positively correlated with blood glucose and blood cholesterol. Conclusion OX-LDL may be involved in the occurrence and development of ATCI.