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目的:对结肠癌患者术后辅助化疗的预后情况进行分析。方法:对2010年1月至2012年10月期间在我院接受诊断和治疗的140例结肠癌患者的资料进行回顾性分析。所有患者术后经过病理检查确诊,所有患者均接受手术治疗和术后辅助化疗。结果:单因素分析显示组织分化、淋巴转移情况、脉管侵犯、临床分期、肿瘤标记物(CEA和CA19-9)各分级之间差异显著,p<0.05,具有统计学意义;多因素分析显示组织分化程度、淋巴转移情况、临床分期和术前CEA水平是影响结肠癌术后化疗生存的独立预后因素,其中以临床分期对患者预后的影响最大;140例患者化疗后出现的不良反应主要为恶性88例占62.86%、口腔黏膜炎53例占37.86%、腹泻46占32.86%、手足麻木43例占30.71%、血小板减少35例占25.71%。结论:术前诊断时应该结合患者组织分化程度、淋巴转移情况、临床分期和术前CEA水平等可以影响结肠癌术后化疗生存的独立预后因素,做出更为准确、可靠的诊断结论。
Objective: To analyze the prognosis of postoperative adjuvant chemotherapy for patients with colon cancer. Methods: The data of 140 patients with colon cancer diagnosed and treated in our hospital from January 2010 to October 2012 were analyzed retrospectively. All patients were diagnosed postoperative pathology, all patients underwent surgical treatment and postoperative adjuvant chemotherapy. Results: Univariate analysis showed that there was significant difference between the grades of tissue differentiation, lymphatic metastasis, vascular invasion, clinical stage and tumor markers (CEA and CA19-9), p <0.05, and multivariate analysis showed Tissue differentiation, lymphatic metastasis, clinical stage and preoperative CEA level were the independent prognostic factors affecting the survival of postoperative chemotherapy in patients with colon cancer, of which the clinical stage had the greatest impact on the prognosis of patients. The adverse reactions after chemotherapy in 140 patients were mainly Malignant 88 cases accounted for 62.86%, 53 cases of oral mucositis accounted for 37.86%, 46 cases of diarrhea accounted for 32.86%, 43 cases of hand and foot numbness accounted for 30.71%, 35 cases of thrombocytopenia 25.71%. Conclusion: Preoperative diagnosis should be combined with the degree of differentiation of patients with tissue, lymph node metastasis, clinical stage and preoperative CEA levels can affect the survival of patients with colon cancer after chemotherapy independent prognostic factors, to make more accurate and reliable diagnosis.