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雄性幼年大鼠分为4组,为去炎松-A(2.1mg/kg,肌注1次)小剂量组(10·5mg/kg肌注1次)和大剂量组,氢化泼尼松(每日20mg/kg肌注4周)阳性对照组和空白对照组。用药4周末取材,结果小剂量组肾上腺皮质束状外带细胞核密度及肾上腺抗坏血酸含量增高,其余脏器无明显改变。大剂量和阳性对照组肾上腺皮质变薄,细胞核密度增加,趋于萎缩;胸腺淋巴细胞大量减少,出现萎缩,脾脏白髓几乎消失,红髓淋巴细胞也明显减少,表明应用大剂量去炎松-A后将引起肾上腺功能下降,免疫器官萎缩,这必将影响细胞免疫与体液免疫功能。
Male juvenile rats were divided into four groups: triamcinolone-A (2.1 mg/kg, intramuscular injection once), low-dose group (1. 5 mg/kg intramuscularly) and high-dose group, prednisolone ( Daily 20mg/kg intramuscular injection for 4 weeks) positive control group and blank control group. After 4 weeks of medication, the results showed that the nucleus density and adrenal ascorbate content in adrenal cortical bundles increased in the low-dose group, and there was no significant change in other organs. In the high-dose and positive control groups, the adrenal cortex became thinner, the nucleus density increased, and it became atrophic; the thymus lymphocytes decreased greatly, and atrophy appeared. The white pulp in the spleen almost disappeared, and lymphocytes in the red pulp also decreased significantly, indicating the use of high-dose triamcinolone- After A, it will cause the decline of adrenal function and the shrinkage of immune organs, which will definitely affect cellular immunity and humoral immunity.