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目的探索培哚普利对慢性心力衰竭患者血清白细胞介素-6(IL-6)水平的影响。方法 40例慢性心力衰竭患者,随机分成对照组和观察组,各20例。对照组采用常规治疗,观察组在常规治疗的基础上加用培哚普利,选取同期门诊健康体检者20例作为健康组。检测40例慢性心力心衰竭患者和20例健康自愿者血清白细胞介素-6水平。比较两组慢性心力衰竭患者的临床疗效,比较慢性心力衰竭患者与健康体检者血清白细胞介素-6水平。结果治疗前慢性心力衰竭患者的血清白细胞介素-6水平显著高于健康组,差异有统计学意义(P<0.01);1个月后观察组的血清白细胞介素-6水平及心室率较对照组明显降低,左心室射血分数(LVEE)较对照组明显增高,差异有统计学意义(P<0.05)。结论培哚普利可以明显降低慢性心力衰竭患者血清白细胞介素-6水平,有助于促进慢性心力衰竭患者的心功能恢复。
Objective To explore the effect of perindopril on serum interleukin-6 (IL-6) level in patients with chronic heart failure. Methods Forty patients with chronic heart failure were randomly divided into control group and observation group, 20 cases each. In the control group, routine treatment was used. In the observation group, perindopril was added on the basis of routine treatment, and 20 healthy subjects in the same period were selected as the healthy group. Serum interleukin-6 levels were measured in 40 patients with chronic heart failure and 20 healthy volunteers. The clinical efficacy of two groups of patients with chronic heart failure was compared, and the level of serum interleukin-6 in patients with chronic heart failure and healthy subjects was compared. Results The levels of serum interleukin-6 in patients with chronic heart failure before treatment were significantly higher than those in healthy controls (P <0.01). After 1 month, serum interleukin-6 level and ventricular rate The control group was significantly lower, left ventricular ejection fraction (LVEE) was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion Perindopril can significantly reduce serum interleukin-6 levels in patients with chronic heart failure and promote the recovery of cardiac function in patients with chronic heart failure.