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目的:探讨脑苷肌肽联合高压氧治疗高原脑水肿患者的临床疗效及对NSE水平的影响。方法:将我院神经内科2011年1月—2013年12月收治的30例重型高原脑水肿患者,采用随机数字表法分为观察组和对照组各15例。两组患者均给予高压氧及常规治疗,观察组患者在此基础上加用脑苷肌肽治疗,比较两组患者的临床疗效,观察治疗前后患者的血清神经元特异性烯醇化酶(NSE)水平。结果:观察组患者的治疗1周后总有效率为66.67%,显著高于对照组患者的46.67%,治疗2周后总有效率为93.33%,高于对照组患者的80.00%,差异有统计学意义(P<0.05)。两组患者治疗后的NSE水平均较治疗前有所改善(P<0.05),但观察组患者改善情况优于对照组患者,差异有统计学意义(P<0.05)。结论:采用脑苷肌肽联合高压氧治疗重型高原脑水肿患者,能够有效降低NSE水平,保护脑细胞,促进神经功能的恢复,缩短患者病程,临床疗效确切。
Objective: To investigate the clinical efficacy and the effect on NSE of patients with high altitude cerebral edema treated with cerebroside and hyperbaric oxygen. Methods: Thirty patients with severe high altitude cerebral edema admitted from January 2011 to December 2013 in our hospital were divided into observation group and control group by random number table. Both groups were given hyperbaric oxygen and routine treatment. The patients in the observation group were treated with cerebroside, and the clinical efficacy was compared between the two groups. The levels of serum neuron specific enolase (NSE) before and after treatment were observed . Results: In the observation group, the total effective rate was 66.67% after one week of treatment, which was significantly higher than that of the control group (46.67%). After 2 weeks of treatment, the total effective rate was 93.33%, which was higher than that of the control group (80.00%) Significance (P <0.05). The levels of NSE after treatment in both groups were significantly improved (P <0.05), but the improvement in observation group was better than that in control group (P <0.05). Conclusion: Cerebroside glycoside combined with hyperbaric oxygen treatment of patients with severe plateau cerebral edema, can effectively reduce NSE levels, protect brain cells, promote the recovery of nerve function, shorten the course of patients, the exact clinical efficacy.