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ＤＮＡ双链断裂 (ＤＮＡｄｏｕｂｌｅ ｓｔｒａｎｄｂｒｅａｋ ,ＤＳＢ)是一种最严重的ＤＮＡ损伤 ,是基因突变 ,染色体断裂的主要原因之一 ,并对肿瘤发生、发展具有一定影响。修复ＤＳＢ主要是通过同源重组 (ｈｏｍｏｌｏｇｙｒｅｃｏｍｂｉｎａｔｉｏｎ ,ＨＲ)和非同源末端连
DNA double strand break (DNA double strand break, DSB) is one of the most serious DNA damage, is one of the main causes of gene mutation and chromosome rupture, and has certain influence on tumorigenesis and development. Repair DSB is mainly through homologous recombination (homologyrecombination, HR) and non-homologous end-linked