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慢性炎症和纤维化疾病都以炎性细胞和介质的聚集为特征 ,并且细胞外基质及纤溶酶系统均有明显的改变。目前发现 ,纤溶酶原激活系统的改变是肺纤维化发展中一个非常关键的环节。研究表明各种肺纤维化患者的支气管灌洗液 (BAL)中纤溶酶原活性受到的损害往往是由于尿激酶型纤溶酶原激活物 (uPA)缺失 ,以及纤溶酶原激活因子抑制物 1(PAI 1)表达增加所致。
Chronic inflammatory and fibrotic diseases are characterized by the aggregation of inflammatory cells and media with marked changes in extracellular matrix and plasmin system. It has been found that changes in the plasminogen activator system is a key link in the development of pulmonary fibrosis. Studies have shown that the impairment of plasminogen activity in bronchoalveolar lavage fluid (BAL) in various pulmonary fibrosis patients is often attributed to the loss of urokinase-type plasminogen activator (uPA) and the inhibition of plasminogen activator 1 (PAI 1) expression increased.