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研究表明，内皮细胞（ＥＣ）的损伤与内毒素的作用有密切关系〔１，２〕，但其机制尚未完全明确。一氧化氮（ＮＯ）既是一种信使分子，又是一种毒性分子〔３〕。炎性或免疫性刺激下产生的大量ＮＯ，可与超氧阴离子（Ｏ÷２）等自由基反应，生成毒性更强的过氧亚硝基阴离子...
Studies have shown that endothelial cell (EC) damage and the role of endotoxin has a close relationship [1,2], but the mechanism is not yet fully clear. Nitric oxide (NO) is both a messenger molecule and a toxic molecule [3]. A large number of NO produced by inflammatory or immune stimuli can react with free radicals such as superoxide anions (O ÷ 2) to form more toxic peroxynitrite anion.